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  • 8150: biological process
    • 5575: cellular component
      • 3674: molecular function
        • 2: Bacteria
          • 2157: Archaea

            GORBI contains millions of predicted gene functions for >900 Bacteria and Archaea. You can search the database by the genome of interest, or by a particular Gene Ontology category, or by individual genes.

            GORBI examines presence/absence patterns of gene orthologs and paralogs across prokaryotic genomes. We use machine learning to accurately infer new GO annotations for genes. 

            1.3 million annotations were made at a stringent FDR<10%. We validated 38 predictions experimentally in E. coli, suggesting that our confidence estimates are correct.

            example #1, tRNA aminoacylation for protein translation #2, ATP-binding cassette (ABC) transporter complex #3 metal cluster binding
            ... or just start typing for a drop-down menu:
            Browse Gene Ontology



            E. coli, Escherichia coli K-12 B. subtilis, Bacillus subtilis subsp. subtilis 168 P. aeruginosa, Pseudomonas aeruginosa PA01
            S. pneumoniae, Streptococcus pneumoniae TIGR4 H. pylori Helicobacter pylori ATCC 700392 ... or >900 others:
            Browse the taxonomy
            note: GORBI version 2015 currently shows predictions only for 17 common Bacteria and Archaea. More microbes are coming soon!

            example #1, #2, #3
            GORBI understands a variety of protein identifiers and Entrez GeneIDs. Just start typing for a drop down menu.



            With higher precision, we expect a higher fraction of true predictions in the results. "Highest," "high," and "moderate" denote precision greater than or equal to 90%, 70%, and 50%, respectively.
            Exclude very broad GO terms (recommended)

            If you found GORBI useful in your work, please cite:
            Škunca N, Bošnjak M, Kriško A, Panov P, Džeroski S, Šmuc T, Supek F (2013) Phyletic Profiling with Cliques of Orthologs Is Enhanced by Signatures of Paralogy Relationships. PLoS Comput Biol 9(1): e1002852. doi:10.1371/journal.pcbi.1002852

             

            ••• The newest datasets from Vidulin et al. Bioinformatics 2016 (under review) are available here. They include annotations of 1,227 Gene Ontology terms to >5,000,000 genes in 2,071 microbial genomes predicted using five orthogonal genome-based methodologies. •••

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            GORBI: Gene Ontology at Ruđer Bošković Institute by http://gorbi.irb.hr is licensed under a Creative Commons Attribution-Non-Commercial-Share Alike 3.0 Croatia License.